20 Pragmatic Free Trial Websites Taking The Internet By Storm

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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often characterized as focusing on practical aspects of design which include recruitment and consent, adherence and the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used different investigators and had participants from different geographical regions. This type of heterogeneity, that is crucial for pragmatic trials to be reliable and reduce bias in results is also essential. However excessive heterogeneity could result in issues with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are usually requested by practitioners and policy makers to guide their decision-making. They can also be used to determine the causality of an intervention and its results. However, they shouldn't be used to substitute for the use of explanation studies.

The idea of pragmatism is controversial and there are concerns about whether pragmatic trials can replace tests for explanations or if they should be an addition to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which support the physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic trial which includes the recruitment process, the design and delivery of the intervention, as well as monitoring.

The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and 프라그마틱 공식홈페이지 pragmatic, limited to controlled trials that are randomized (RCTs), yielded 34 articles, shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember, however, that the majority of studies were conducted in primary-care settings.